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Antiphospholipid syndrome and Deep Vein Thrombosis (DVT) Buffalo
Wednesday, December 12, 2012

 

What is the antiphospholipid syndrome ? Antiphospholipid syndrome and DVT Buffalo

 

 

 

 

Antiphospholipid antibodies are found in 1% to 5% of the population and the prevalence increases with age.

 

The antihospholipid antibody syndrome is a clinical disorder where patients can develop recurrent episodes of arterial and venous thrombosis. Another name (misnomer) is lupus anticoagulant syndrome. The current terminology is to call it antiphospholipid syndrome with or without associated rheumatologic disease.

 

The procoagulant effects of the antiphospholipid antibodies lead to thrombosis and this is mediated through inhibition of the activated protein C pathway, inhibition of antithrombin activity, inhibition of the anticoagulant activity of beta glycoprotein I, inhibition of fibrinolysis and activation of platelets.

 

The most important complication from the antiphospholipid syndrome is venous clots and thromboembolism and less commonly, arterial clotting. Prophylaxis is achieved with oral aspirin and hydroxychloroquin.

 

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