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Matrix Metalloproteinases and Varicose Veins
Sunday, February 3, 2013

 

 

According to researchers, at Harvard Medical School, "prolonged increases in venous pressure and vein wall tension are thought to increase the expression/activity of matrix metalloproteinases (MMPs). - collagenases, gelatinases, stromelysins, matrilysins, among others".

 

According to Kucukguven and Khalil at Harvard Medical School Brigham and Women's Hospital Division of Vascular Surgery, "MMPs may also affect the endothelium and vascular smooth muscle, causing changes in the vein relaxation and contraction mechanisms. This  injury also triggers leukocyte infiltration, activation and inflammation, which lead to further vein wall damage. The vein wall dilation and valve dysfunction, and the MMP activation and superimposed inflammation and fibrosis would lead to progressive venous dilation and varicose vein formation".

 

The authors concluded that "with the advent of new genetic and pharmacological tools, specific MMP inhibitors with fewer undesirable effects could be useful to retard the progression and prevent the recurrence of [varicose veins]".

 

The study is published in Curr Drug Targets. 2013 Jan 7.

 

Call Dr. Karamanoukian in Buffalo Niagara to schedule an appointment for consultation - call 716-839-3638 or www.VeinsVeinsVeins.com and www.VeinGuide.com

 

Dr. Hratch Karamanoukian is a member of the American College of Phlebology AND a Diplomate of the American Board of Phlebology. He can be contacted by calling 716-839-3638 or www.VeinsVeinsVeins.com 

 

Dr. Raffy Karamanoukian is a member of the American College of Phlebology AND a Diplomate of the American Board of Phlebology. He can be contacted by calling 310-998-5535 or www.SantaMonicaVeinCenter.com 

 

Drs. Raffy and Hratch Karamanoukian have authored 6 books about venous disease. The books are available on Amazon Kindle and Nook books for download.

 

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