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Matrix metalloproteinases and varicose vein formation -
Sunday, February 24, 2013






According to researchers, at Harvard Medical School, "prolonged increases in venous pressure and vein wall tension are thought to increase the expression/activity of matrix metalloproteinases (MMPs). - collagenases, gelatinases, stromelysins, matrilysins, among others".


According to Kucukguven and Khalil at Harvard Medical School Brigham and Women's Hospital Division of Vascular Surgery, "MMPs may also affect the endothelium and vascular smooth muscle, causing changes in the vein relaxation and contraction mechanisms. This  injury also triggers leukocyte infiltration, activation and inflammation, which lead to further vein wall damage. The vein wall dilation and valve dysfunction, and the MMP activation and superimposed inflammation and fibrosis would lead to progressive venous dilation and varicose vein formation".


The authors concluded that "with the advent of new genetic and pharmacological tools, specific MMP inhibitors with fewer undesirable effects could be useful to retard the progression and prevent the recurrence of [varicose veins]".


The study is published in Curr Drug Targets. 2013 Jan 7.




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