Physiologic changes of clotting factors during pregnancy include:

Elevated circulating levels of Factor VII, Factor VIII, Factor X and Factor XII during pegnancy increase risk of developing venous thromboembolism. This risk is highest right after delivery of the baby (the puerperium).

There are also a reduction in sensitivity to activated protein C and functional protein S levels during pregnancy.

The risk of develoing venous thromboembolism during pregnancy is 0.66 per 100.

This data is from P Kesteven and colleagues and the article is published in Phlebology 2012; volume 27 Supplement: pages 73-80.

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