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DVT (deep vein thrombosis) is multifactorial - Dr. Karamanoukian - Treatment Varicose Veins Buffalo Niagara and Peace Bridge Healthcare
Saturday, August 10, 2013




It needs to be recognized that deep vein thrombosis formation is a multifactorial process, meaning that risk factors have to be present before deep vein thrombosis occurs in most patients.  This is reflected in a the scientific literature which clearly shows increased risk for developing deep vein thrombosis (DVT) for certain groups.  These include patients with Factor V Leiden mutations, those who use oral contraceptives and those who are obese.  As well there is an increase risk for tall and short people.



Patients with all risk factors who plan to travel, the benefits and risks of deep vein thrombosis prophylaxis need to be individually discussed.  Passengers who develop deep vein thrombosis have a risk factor and this is in order of frequency from the highest risk to the lower risk is



1. Thrombophilia. 

2. Use of oral contraceptive pill. 

3. Previous deep vein thrombosis. 

4. Recent injury to the lower extremity or surgery to the lower extremity.

5. Presence of varicose veins

6. Obesity.



Two or more combined risk factors markedly increase the risk of developing deep vein thrombosis. 



There is no evidence to support an increase risk of developing deep vein thrombosis when you consider the following risks:



1. Age or gender of travel passenger

2. Drinking alcohol during flight   

3. Use of sleeping pills

4. Seating arrangements 

5. Cabin environment

6. Physical activity or lack of physical activity during airplane travel



Of course even though there is no clear objective evidence to support the fact that physical activity or lack of physical activity does not significantly increase the risk of deep vein thrombosis, this should not be ignored.  Walking regularly every hour and exercising the lower extremities with foot pedal movements will activate the calf muscles and pump stagnant blood out of the legs. 



The use of class one support stockings have been shown to literally eliminate the risk of developing deep vein thrombosis in passengers known to be at higher risk of developing deep vein thrombosis.  



Low molecular weight heparin injections have also been shown to reduce the risk of developing deep vein thrombosis. 



Aspirin has been shown to be of no valve in preventing deep vein thrombosis as clotting in deep vein thrombosis formation is related to fibrin production and not to platelet activation.



To learn more about deep vein thrombosis contact Hratch Karamanoukian, MD FACS at the Vein Treatment Center or go to and call 716-839-3638.



If you believe you have a deep vein thrombosis while on travel, go directly to an emergency room for evaluation with a duplex venous ultrasound or call your primary care physician for guidance. and are partners with






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