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Chronic Cerebrospinal Venous Insufficiency (CCSVI) treatment and multiple Sclerosis (MS) at University at Buffalo
Friday, August 16, 2013



In February of 2010 the first blinded study of venous insufficiency prevalence in multiple sclerosis patients showed promising results.


Studies at the University of Buffalo looked to validate whether multiple sclerosis patients have disease in the extracranial veins. The UB study was the initial phase of the first randomized clinical study to determine if persons with multiple sclerosis exhibit stenosis or narrowing of the extracranial veins. The cause of this stenosis resulted in restriction of normal outflow or egress of blood from the brain.  When the 10% or more subjects in which results were borderline were excluded from the study results, the percentage of affected multiple sclerosis patients rose to 62.5%.  This was compared to 25% of healthy controls who had narrowing or stenosis of their extracranial veins.


However, a study reported by Canadian scientists recently found no evidence of stenosis in multiple sclerosis patients.


Canadian scientists visited an Italian center to validate the findings of extracranial vein disease as reported by Dr Paolo Zamboni. Researchers from McMaster University in Ontario concluded that they could not find any blockages in the internal jugular, vertebral or deep cerebral veins in 99 of 100 patients with multiple sclerosis compared to 100 controlled subjects with no history of multiple sclerosis.  The researchers conducted ultrasound studies and magnetic resonance imaging on the head and neck veins of all studied subjects.


The Italian researcher Dr. Paolo Zamboni was first to suggest that chronic cerebral spinal venous insufficiency is linked to multiple sclerosis and he reported further that patient’s symptoms were alleviated after undergoing angioplasty or venoplasty to clear the blockages.  This type of stenting procedures have since been termed “Liberation Therapy” for multiple sclerosis (MS) patietns.


Dr. Zamboni commented on this study which was published in PLOS ONE. He  stated that the researcher from McMaster University did not follow the recommended protocol for ultrasound studies to validate this hypothesis.


CCSVI is being aggressively investigated for the many patients with MS around the world.





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