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What is the best sclerotherapy agent? Vein Treatment Center and Dr. Karamanoukian at
Sunday, August 18, 2013



There is no such thing as the best sclerotherapy solution. But you need to know about the different types of sclerotherapy solutions.


1. Detergent type - STS, polidochanol, sodium morrhuate and ethnolamine. These cause protein theft denaturation and cause fibrosis of the veins. Only sodium morrhuate and ethanolamine have FDA approval.


2. Hyperosmolar hypertonic type - hypertonic saline and hypertonic saline dextrose (HSD) solution. They obiterate veins via a chemical irritation.


3. Chemical irritants - iodinated iodine and glycerin.


Some of these, like STS and Polidochanol, have been used with foam to obliterate larger veins. 


For adequate treatment, go to a phlebologist, a vein specialist and he/she will discuss all of your options with risk/benefit discussion and side effect profiles. Ask about individual risk of tissue necrosis, hyperpigmentation, pain profile with injection, allergic reactions, etc. These are very important questions to ask.


For more information about spider veins, reticular veins and varicose veins, contact Dr. Karamanoukian at the Vein Treatment Centers with offices in Williamsville, New York and Clarence, New York as well as the Advanced Aesthetic Medical Spa (AAMS) in East Amherst, New York or go to,, or call 716-839-3638 to schedule an appointment for consultation. and and are partners with




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