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Antiphospholipid Syndrome and Venous Thromboembolism - Buffalo Niagara Vein Treatment Center and
Wednesday, August 21, 2013



The antiphospholipid syndrome is defined by the presence of two components: 1) The presence in the plasma of at least one type of antibody known as the antiphospholipid antibody  and  2) The occurrence of at least one of the following - venous thrombosis, arterial thrombosis, or pregnancy related complications.


The antiphospholipid antibodies are directed against plasma proteins in the body that are bound to negatively charged phospholipids (anionic phospholipids) and are detected as the lupus anticoagulants, anticardiolipin antibodies, and antibodies to beta 2 Glycoprotein-1.


There are other antibodies against gene products such as the prothrombin gene, and phosphatidylserine – the relevance of these antibodies are not fully understood.


It has also been shown that the antiphospholipid syndrome occurs either in isolation or in the setting of an underlying disease such as system lupus erythematosus (SLE).


There are a variety tests that can detect antiphospholipid syndrome  and these include - anticardiolipin antibodies, antibodies to anti-beta 2-glycoprotein 1 and functional assays to detect antiphospholipids with lupus anticoagulant activity.


For information regarding antiphospholipid syndrome and treatment of deep vein thrombosis, contact Hratch Karamanoukian, MD FACS at the Vein Treatment Center with offices in Williamsville, New York and Clarence, New York.  Dr. Karamanoukian is board certified in phlebology (venous diseases and diseases and disorders).  Contact information is through or or by calling 716-839-3638. and are partners with



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