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Pharmacologic agents in the treatment of venous reflux disase - Diosmin - Bioflavonoids -
Monday, November 26, 2012


A study published by the Imperial Vascular Unit, Charing Cross Hospital, London, UK looked at the published databases for 'purifeid flavonoid fraction' and 'venous reflux'.


The study was published in the Current Vascular Pharmacology 2009; volume 7, 303-308.


Study author was MS Gohel and A Davies.


The study showed that "A wide range of venoactive and non-venoactive drugs have been studied in patients with venous disease. The use of micronized purified flavonoid fraction (Daflon) can reduce symptoms of pain, heaviness and oedema in patients with venous reflux and a recent meta-analysis concluded that Daflon improves healing in patients with venous ulceration treated with compression. Pentoxifylline may be a useful adjunct to compression therapy for patients with venous ulceration. Oxerutins and calcium dobesilate may be of benefit in reducing oedema and rutosides may help to relieve the symptoms of varicose veins in pregnancy. The clinical benefits of other medications remain unproven. Although numerous pharmacological agents have been proposed and studied, Daflon has demonstrated the greatest clinical benefits in patients with venous disease. Further research is needed to define the role of venoactive drugs in clinical care and improve our understanding of the pathophysiology of venous disease to help identify new therapeutic avenues."


for a bioflavonoid formula developed by Dr Karamanoukian, go to and look at Varicosamin.


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