Schedule a Consultation
(716) 839-3638
Diosmin and venous insufficiency - Diosmin and venous reflux - Varicosamin on
Saturday, December 1, 2012


from Sandra Marinovic Kulišic, MD, PhD, University Hospital Center Zagreb , Department of Dermatology and Venereology , School of Medicine, University of Zagreb , Šalata 4, HR-10000 Zagreb, Croatia


This summary of the benefits of Diosmin was published in an abstract in Acta Dermatovenerol Croat. 2012 OcTOBER, volume 20(3): pages 197-200.


The title of the abstract is Pharmacologic Treatments in Patients with Chronic Venous Disease.


****Part of the absract is shown here verbatim*****


Diosmin and its derivative micronized purified flavonoid fraction (MPFF), consisting of 450 mg diosmin and 50 mg other flavonoid components (hesperidin, linarin, and isorhoifolin), are widely used to relieve symptoms of chronic venous insufficiency (CVI). Of particular interest is the action of MPFF on inflammatory reactions associated with venous hypertension, inhibition of leukocyte activation, adhesion and migration. Specifically, MPFF modifies leukocyte endothelial interactions, inhibiting the expression of intercellular adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM), as well as the expression of leukocyte adhesion molecules on monocytes and neutrophils (4). The mechanisms of action prevent endothelial damage and suggest use of the drug in the early and advanced stages of CVI (5). The capillary protective effect is enhanced by micronization (6). Unlike other venoactive drugs, MPFF has proven efficacy in ulcer healing. In a meta-analysis of five prospective randomized controlled trials involving 723 patients with venous ulcers in which MPFF therapy was compared with compression therapy, alone in three studies and combined with placebo in two studies (7), the possibility of healing was by 32% higher in the MPFF-treated patients after 6 months and the healing time was shorter (16 weeks versus 21 weeks).


Dr. Karamanoukian recommends a product called Varicosamin for venous insufficiency which can be purchased on

© 2012 Vein Guide, Inc. All rights reserved.