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Pentoxiylline for venous ulcers
Saturday, December 1, 2012


from Sandra Marinovic Kulišic, MD, PhD, University Hospital Center Zagreb , Department of Dermatology and Venereology , School of Medicine, University of Zagreb , Šalata 4, HR-10000 Zagreb, Croatia


This summary of the benefits of pentoxyfilline published in an abstract in Acta Dermatovenerol Croat. 2012 OcTOBER, volume 20(3): pages 197-200.


The title of the abstract is Pharmacologic Treatments in Patients with Chronic Venous Disease.


****Part of the absract is shown here verbatim*****


Pentoxifylline was the first drug to be extensively studied. It is a xanthine derivative with evidence for a range of microcirculatory effects including reduced platelet aggregation and white cell activation (15). A Cochrane review published in 2007 included 12 randomized trials with 864 participants (16). Pentoxifylline plus compression therapy was found to be more effective than placebo plus compression for ulcer healing (RR 1.54; 95% CI 1.14-2.13). The current use of this drug is, however, limited by the frequent occurrence of side effects (chiefly gastrointestinal) and because it is not reimbursable.


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