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Who is at risk for developing postthrombotic syndrome ? PTS - post thrombotic syndrome risk
Sunday, December 2, 2012


These are some facts taken from Dr. Karamanoukian's book about post thrombotic syndrome:


According to the latest medical research, there are some general statistics that can be applied to help you understand if you are at risk for developing PTS.


  • 60% of patients with DVT will NOT develop post thrombotic syndrome. This means you have a better than 50/50 chance of not developing the condition at all. However, some studies show that this percentage is closer to 50%, depending on other factors.


  • 30% of patients who suffer from DVT will have some symptoms of post thrombotic syndrome, though these symptoms can vary significantly from one patient to another. The severity of symptoms can also vary significantly.


  • 5% of patients who suffer from DVT will go on to develop severe post thrombotic syndrome that requires significant treatment to correct or mitigate. Severe symptoms can include leg ulcers, extreme pain and edema, “bursting” pain and limited mobility to name only a few.


  • If you have not suffered any symptoms of PTS in one and a half to two years after treatment for deep venous thrombosis, chances are that you will not develop post thrombotic syndrome at all. However, your doctor may recommend that you continue wearing compression stockings, though the compression strength may be adjusted.


  • Patients with ‘proximal’ DVT (upper calf) have a higher chance of developing post thrombotic syndrome (15% of patients). Thigh DVT or calf-to-thigh DVT seems to be the most common precursor to PTS.


  • There is no means to predict who will or will not develop post thrombotic syndrome with any degree of accuracy.



  • Interestingly, PTS is less common in patients with Factor V Leiden or the Prothrombin II gene mutation according to Khan and colleagues who have published an article called ‘Predictors of the PTS during long term treatment of proximal DVT’ (J Thrombosis and Haemostasis, volume 3, pages 718-723, 2005).



Dr. Hratch Karamanoukian is a member of the American College of Phlebology AND a Diplomate of the American Board of Phlebology. He can be contacted by calling 716-839-3638 or 



Dr. Raffy Karamanoukian is a member of the American College of Phlebology AND a Diplomate of the American Board of Phlebology. He can be contacted by calling 310-998-5535 or 


Drs. Raffy and Hratch Karamanoukian have authored 6 books about venous disease. The books are available on Amazon Kindle and Nook books for download.

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